慢性心力衰竭患者不同方法治疗前后纤维化指标初步观察

Comparison for contents of index of fibrosis before and after treatment in patients with chronic heart failure

目的 :比较不同心功能级数慢性心力衰竭 (CHF)患者治疗前后血清Ⅲ型前胶原 (PCⅢ )、透明质酸 (HA)和层粘蛋白(LN)含量的变化 ,研究心肌纤维对该病的影响。方法 :用放射免疫法对 84例慢性心力衰竭 (CHF)患者血清PCⅢ ,HA和LN含量进行测定。结果 :84例CHF患者血清PCⅢ ,HA和LN含量分别为 ( 180 3 3± 3 2 5 6) μg·L-1,( 88 2 5± 2 9 14) μg·L-1和( 13 2 45± 2 6 3 3 ) μg·L-1,与正常对照组比较有显著性差异 (P均 <0 0 1) ;心功能Ⅱ级和Ⅲ级患者上述纤维 3项指标水平明显高于心功能Ⅰ级者 (P <0 0 5 ) ,且升高程度与心功能级数相平行 ;不同心功能级数CHF患者血清PCⅢ ,HA和LN纤维 3项指标含量治疗后较治疗前明显降低 (P <0 0 5～ 0 0 1)。结论 :CHF患者PCⅢ ,HA和LN含量升高 ,可能与心功能有关 。

AIM: To detect contents of type Ⅲ prophase-collagen (PCⅢ), hyaluronic acid (HA) and laminin (LN) in different function degree before and after treatment in patients with chronic heart failure (CHF) and to research myocardial the fiber to influence that disease. METHODS: Radioimmunoassay (RIA) was used to measure the changes of the serum contents of PCⅢ, HA and LN of 84 examples of CHF. RESULTS: The contents of PCⅢ, HA and LN in 84 patients with CHF were (180.33±32.56) μg·L -1, (88.25±29.14) μg·L -1 and (132.45±26.33) μg·L -1, respectively, obviously higher than those of the normal (P<0.01); Heart function stageⅡ and stageⅢ were obvious higher than heart function stageⅠ (P<0.05). It was found that above contents were paralleled with degree and heart function stage for distinct heart function degree of CHF, the index of fibrosis cut down obviously after treatment (P<0.05-0.01). CONCLUSION: The results show that the obvious rise of PCⅢ, HA and LN in CHF patients is related to heart function. The antifibrosis treatment of CHF has positive therapeutic effect by the myocardial antifibrosis.