重组人表皮生长因子对宫颈糜烂物理治疗后创面愈合的影响

Effect of recombinant human epithelial growth factor on recovery of the wound of cervical erosion treated physically

目的 :探讨宫颈糜烂物理治疗后局部喷洒重组人表皮生长因子 (rhEGF)对宫颈创面愈合的影响及安全性。方法 :将5 14例中、重度宫颈糜烂的患者分为冷冻 +rhEGF组 (A组 ,n =118)和冷冻对照组 (B组 ,n =10 4) ,电熨 +rhEGF组 (C组 ,n =15 2 )和电熨对照组 (D组 ,n =140 )。治疗前做宫颈的细胞学检查 ,排除宫颈上皮的异常变异。A与C组在宫颈糜烂物理治疗后 ,使用rhEGF作宫颈的局部喷洒 ,每天一次 ,在宫颈物理治疗后的 3mo,作疗效的判断 ,并在 3 ,6,12mo时随访宫颈刮片检查。对照组给NS局部喷洒。结果 :A组和B组的治愈率分别为 92 4%和 81 7% ;宫颈创面愈合时间分别为 5 8d和 79d ;阴道排液时间分别为 2 5d和 3 9d ;生殖系统感染率分别为 1 69%和 8 65 % ;阴道排液量A组比B组有明显减少 ;以上 2组比较 ,P均 <0 0 5。C组和D组治愈率分别为 96 1% ,85 6% ;宫颈创面愈合时间分别为 45d ,63d ;阴道排液时间分别为 17d ,3 0d ;生殖系统感染率分别为 1 3 4% ,7 86% ;以上 2组比较 ,Ρ均 <0 0 5。C组阴道排液量与D组无明显差别 (Ρ >0 0 5 )。宫颈细胞学检查 ,所有患者未发现宫颈的上皮细胞有异常增生的改变。未发现有过敏或其他的药物不良反应。结论 :rhEGF能促进宫颈糜烂物理治疗后创面愈合 ,提高治愈率 ;未发?

AIM: To evaluate effect of recombinant human epithelial growth factor (rhEGF) sprayed locally on recovery of the wound of cervical erosion treated physically and safety of rhEGF. METHODS: A total of 514 patients with uterine cervical erosion Ⅱ, Ⅲ were divided into freezing+rhEGF (A, n=118), freezing+saline (B, n=104), electrocoagulation+rhEGF (C, n=152), electrocoagulation+saline (D, n=140) groups. Cytology scanning of cervix had been done for all the patients before administration in order to exclude cervical intraepithelial neoplasia. The wound of cervix was sprayed with rhEGF one time each day after cervical erosion treated through freezing or electrocoagulation in researched groups (A and C). The results of treatment were evaluated after 3 mo the erosion of cervix treated physically. Smear of cervix was followed repeatedly normal in 3 mo, 6 mo, and 12 mo after treatment. Controlled groups (B and C) were administrated saline. RESULTS: The healing rates were 92.4% and 81.7%, the period of recovery from the wound of cervix was 58 d and 79 d, the duration of vaginal discharge was 25 d and 39 d, the rate of reproductive infection was 1.69% and 8.65%, in the group A and group B respectively. The quantity of vaginal discharge in group A was much less than group B. Significances were found between group A and group B (Ρ<0.05). The healing rates were 96.1% and 85.6%, the period of recovery from the wound of cervix was 45 d and 63 d, the duration of vaginal discharge was 17 d and 30 d, the rate of reproductive infection was 1.34% and 7.86%, in the group C and group D respectively. Significances were found between group C and group D (Ρ<0.05). The quantity of vaginal discharge in group C was as same as in group D (Ρ>0.05). Cervical intraepithelial neoplasia was not found in the all patients through scanning of cervical smear. Adverse drug reactions and allergy reaction were not observed. CONCLUSION: rhEGF accelerates recovery of the wound of cervical erosion treated physically. The healing rate of cervical erosion was elevated through rhEGF sprayed locally. Hyperstimulation of cervical epithelia was not found in used rhEGF groups.