果蝇Presenilin蛋白影响神经肌肉接点分布

PRESENILIN PROTEIN IMPACTING SYNAPTIC SPROUTING ON NEUROMUSCULAR JUNCTION OF DROSOPHILA

为观察 Presenilin蛋白对突触可塑性的影响 ,本研究以果蝇神经肌肉接点分布为模型 ,发现 Presenilin突变 Psns3可导致神经肌肉接点数量的明显减少 ,而且当提高温度后 ,可造成接点数量的进一步减少。提示 ,Presenilin蛋白参与了突触的形成过程 ,进而可能会影响到学习记忆。结果还提示 。

In order to investigate the role of Presenilin protein on synaptic plasticity, we used the model of neuromuscular junction in larvae of Drosophila. We found that the number of varicosities in Psn s3 mutants decreased significantly and the decrease was enhanced when we raised the temperature. Our results indicate that Presenilin proteins are involved in the formation and plasticity of synapses, which appears to affect the learning and memory. Furthermore, the temperature may play a role in maintaining the conformation and the function of mutated Presenilin protein.