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2型糖尿病血清炎症介质水平及血白细胞变化 被引量:8

Changes in Serum Inflammation Media and Peripheral WBC in Type 2 Diabetes
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摘要 目的 :研究 2型糖尿病患者炎症因子C反应蛋白 (CRP)、肿瘤坏死因子α(TNF α)、IL 6浓度及外周血白细胞水平变化。方法 :选择健康成人 30例 ,高血压病人 30例 ,2型糖尿病病人 4 5例 ,测定各组人群超敏C反应蛋白 (Hs CRP)、TNF α、IL 6、白细胞 (WBC)水平 ,观察炎症介质在各组人群中的差异。结果 :高血压组和 2型糖尿病组的血清炎症介质水平较基础值均有升高 ,而糖尿病组血清炎症介质水平上升更明显 ,与另两组差异有显著性。结论 :2型糖尿病病人存在高水平炎症介质 ,即有炎症反应存在。 Objective:To investigate the changes in concentration of serum inflammation media (CRP?TNF-α?IL-6) and peripheral WBC counter in type 2 diabetes .Methods:Selected 30 normal individuals,30 hypertension individuals and 45 type 2 diabetics to test their hs-CRP? TNF-α?IL-6 and WBC.Result:Inflammation media of hypertension group were higher than controls(CRP? TNF-α,P<0.05), and in type 2 diabetics they were significantly higher than hypertension individuals(P<0.01).Conclusion:Type 2 diabetics had higher level inflammation media.
作者 孔宪如
出处 《江苏大学学报(医学版)》 CAS 2004年第2期139-141,共3页 Journal of Jiangsu University:Medicine Edition
关键词 2型糖尿病 炎症介质 Type 2 diabetes Inflammation media
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参考文献10

  • 1American Diabetes Association.Screening for type 2 diabetes[J].Diabetes Care,200,23(suppl):20-23.
  • 2Martin-du Pan RC,Despont JP. High-sensitivity C-reactive protein: a new risk factor of coronary disease[J].Rev Med Suisse Romande,2002,122(3):163-166.
  • 3Brazilay JI,Abraham L,Heckbert SR,et al.The relation of markets inflamamation to the development of glucose disorders in the elderly:the Cardiovascular Health study[J].Diabetes,2001,50:2384-2389.
  • 4叶丹,李红.炎症反应相关因子与2型糖尿病[J].国外医学(内分泌学分册),2003,23(5):312-314. 被引量:44
  • 5Pradhan AD,Manson JE,Nader R,et al.C-reactive protein,interlerkin-6,and risk of developing type 2 diabetes mellitus[J].JAMA,2001,327-334.
  • 6董吉祥,石永兵,韩惠琴,沈华英,谢炜,谢莹,刘志达,张学光.2型糖尿病患者血清白细胞介素-6、肿瘤坏死因子-α水平与T细胞亚群变化的研究[J].中华内分泌代谢杂志,1999,15(6):370-371. 被引量:21
  • 7Philip A,Subramanian R,Chunling L,et al.Adipose tissue tumor necrosis factor and interleukin-6,express in obesity and insulin resistance[J].Am J Physiol Endocrinol Metab,2001,280:745-751.
  • 8Freeman DJ, Norrie J, Sattar N, et al. Pravastatin and the development of diabetes mellitus: evidence for a protective effect in the West of Scotland Coronary Prevention Study[J]. Circulation, 2001,103: 357-362.
  • 9Levi Z, Shaish A, Yacov N,et al. Rosiglitazone (PPARgamma-agonist) attenuates atherogenesis with no effect on hyperglycaemia in a combined diabetes atherosclerosis mouse model[J]. Diabetes Obes Metab,2003,5(1):45-50.
  • 10Noriko Satoh, Yoshihiro Ogawa, Takeshi Usui,et al. Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect[J].Diabetes Care,2003,26:2493-2499.

二级参考文献29

  • 1Pandolfi A, Gisccari A. Acute hyperglycemia and acute hyperinsulinemia decrease plasm flbrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat [ J ] .Acta Diabetol,2001,38:71-76.
  • 2Yamagishi S, Edelstein D, Du X. et al. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase [ J ]. J Biol Chem,2001,276:25096-25100.
  • 3Unger R H, Zhou Y T. Lipotoxicity of β-cell in obesity and in other causes of fatty acid spillover [ J]. Diabetes, 2001,50(Suppl 1) :S118-S121.
  • 4Barbora V, Christian W, Robert S, et al. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes[J] . Diabetes, 2002,51 : 455-461.
  • 5Robort S, Lindsay J K, Robext L H, et al. Gamma globulin level predict type 2 diabetes in the Pima Indian population[ J] Diabetes, 2001,50 : 1598-1603.
  • 6Walder K,Lakshmi K,Janine S,et al.Tanis: a link between type 2 diabetes and inflammation? [J]. Diabetes,2002,51:1859-1866.
  • 7Pradhan A D, Manson J E, Nader R, et al. C-reactive protein, interleukin-6, and risk of developing type 2 diabetes mellitus[ J] .JAMA ,2001,286:327-334.
  • 8Hrnciar J,Garbor D, Hrnciarova M, et al. Relation between cytokine (TNF-alpha, IL-6 and 1) and homocysteine in android obesity and the phenomenon of insulin resistance syndromes[ J]. Vnilr Lek, 1999,45 : 11-16.
  • 9Esposito K, Nappo F, Marfella R, et al. Inflammation cytokine concentrations are acutely increased by hyperglycemia in human : role of oxidative stress[J ] . Circulation, 2002,106 : 2067-2072.
  • 10Philip A, Subramanian R, Chunling L, et al. Adipose tissue tumor necrosis factor and interleukin-6, expression in obesity and insulin resistance [ J ]. Am J Physiol Endocrinol Metab,2001,280.E745-E751.

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