抗凝血生物材料研究中的表面分析方法

Application of Surface Analysis Methods in Researching Anticoagulant Biomaterials

开发抗凝血生物材料最主要的目的就是要找到一种在与人体血液和组织相接触后不会引起血栓、凝血和炎症等特性的高分子材料,而抗凝血生物材料的以上特性与其表面性质紧密相关。因此,需要对新合成的材料的表面性质进行表征。综述了近年来应用得比较广泛的7种用于抗凝血生物材料表面性质分析的常规方法和1种新兴的核分析方法,并以在研究中的运用为实例,介绍了各种方法的原理、特点以及一些不足,指出只有借助多种分析方法,才能全面了解抗凝血生物材料的表面结构。

The main purpose of researching and designing(R&D) anticoagulant biomaterials is to find a polymer material which possesses some special properties, when it attatches to the blood or tissue of human body, it could not cause clotting, thrombus or inflammation. The properties of anticoagulant biomaterials mentioned is correlated with its surface property. So, the surface property of anticoagulant biomaterials need to be characterized. Seven general surface analysis methods and one novel nuclear method which are used to characterize anticoagulant biomaterials are summarized. The typical references for the application are listed to introduce the theory,advantage and disadvantage of each method. At last it is pointed out that only making full use of these methods can we comprehensively know the surface structure of anticoagulant biomaterials, and then use these information to guide our research.