基因芯片数据的聚类分析

Clustering in DNA chip data analysis

基因芯片技术是后基因组时代功能基因组研究的主要工具。由于采用了高效的并行DNA杂交技术,每次实验可以得到大量丰富的数据,因此其结果分析成为一项很有挑战性而且具有重要意义的工作。聚类分析是基因芯片数据分析中使用广泛的一类方法。基因芯片实验得到的大量数据通过聚类分析,可以得到很多有用的信息,其成功应用已广泛涉及到生物医学研究中的各个领域。本文介绍了基因芯片数据的聚类分析方法及其重要应用。

Microarray technology is the chief tool for functional genomics research. Adopting the high efficient and parallel DNA hybridization technology, we can achieve abundant data from each experiment, so the data analysis of microarrays becomes a challenge and significant task. Clustering is the most useful and widely used method of microarray data analysis. Abundant useful information can be obtained through the microarray clustering. There are many successful examples that have been applied to a wide of research fields of life science. The review presented the methods and applications of clustering analysis in DNA microarrays.