异紫堇定抗猕猴失血性休克的实验研究

Experimental Research on the Anti-Hemorrhagic Shock Effect of Isocorydine in the Monkey

本文报告异紫堇定抗猕猴失血性休克的作用。实验结果表明该药能改善失血性休克猕猴的微血管功能、升高股动脉血压、增加股动脉血流量,但减慢心率。用药20分钟后,再配合输血能使休克猕猴各实验指标迅速恢复正常。这些作用表明异紫堇定具有抗失血性休克的作用。

Isocorydine(Isoc) is an alkaloid isolated from the Chinese herb Dactylicapnos Scandens. Its main pharmacological effect is as a nonspecific vasodilator. Ten rhesus monkeys wighing 7.0+2.0 kg(mean± SD) were bled 152.5± 57.4ml (27.2% of the total blood volume) from the carotid artery to cause hemorrhagic shock. Five monkeys were injected with 5% Isoc (2.5rnl/kg)iv and the other five with the same volume of physiological saline. We observed the changes of the shock for 20 minutes, and then transfused blood for restoration. The femoral arterial pressure, systolic (FAPs) and diastolic (FAPd), auricula arterioles pulse (AAP), femoral arterial blood flow (FAQ) and heart rate (HR) were recorded with an RM-6000 8 channel polygraph. The data were statistically calculated with two-ways analysis of variance and t test. The experimental results showed that in the hemorrhagic shock monkeys, Isoc could improve arterioles function and cardiac muscle contractility and increase cardiac output, FAP and FAQ, but decrease HR. The effects of Isoc as compared with physiological saline were significant (P<0.05). Furthermore, the transfusion effect was better in the Isoc group than in the saline group. Therefore, we consider tLat Isoc is valuable for anti-hemorrhagic shock.