正常成人及肢端肥大症患者的生长激素谱测定

PATTERNS OF GROWTH HORMONE SECRETION IN NORMAL ADULTS AND ACROMEGALIC PATIENTS

对10例正常成人及4例肢端肥大症(肢大)患者进行生长激素(GH)谱测定,正常人GH分泌型式为长期分泌静止,间以脉冲分泌,在第1次深睡后有GH分泌大峰;女性GH分泌波动较男性明显。肢大患者均无夜间GH分泌大峰。2例测24小时GH谱的肢大患者中,1例血糖水平正常男性患者GH分泌峰数增多,另1例并有高血糖女性患者GH分泌频率明显减少。测定结果表明垂体GH分泌瘤的功能虽系自主性,但仍部分受下丘脑释放激素的调控。

The secretory profile of GH was generated by 15-30 minutes sampling in 10 normal adults and 4 acromegalic patients. The 15-and 20-min sampling revealed more GH pulses than 30-min sampling, but the average amplitude of GH pulses and the amount of GH secreted were of the same. The normal females had more GH pulses in morning after waking and in the postabsorptive period after dinner., All .4 acromegalic patients had no big GH peak after the first deep wave sieep. In 2 acromegalic patients who had a 24-hour GH profile measurement, the male patient with normal blood sugar level had more GH pulses, but the female patient with diabetes mellitus had only a few GH pulses. Our results showed that the autonomous GH-secreting tumor remains under hypothalamic control to some extent.