血清骨钙素放射免疫分析的临床初步应用

PRELIMINARY CLINICAL APPLICATIONS OF SERUM BONE Gla PROTEIN RADIOIMMUNOASSAY

用放射免疫分析方法对304例正常成人及内分泌疾病和代谢性骨病患者的血清BGP进行了观察。结果表明,未经治疗的甲亢、原发性甲旁亢、骨软化症、肢端肥大症患者血清BGP显著高于正常对照组。甲减、特发性甲旁减、Sheehan综合征、肾上腺皮质功能亢进症患者血清BGP降低。部分代谢性骨病患者治疗后,血清BGP有不同程度的恢复。这些结果表明,血清BGP测定可以作为这些内分泌疾病及代谢性骨病的诊断、疗效观察的指标之一。

Serum bone Gla protein (BGP) was determined by radioimmunoassay in 304 healthy adults and patients with various endocrine diseases and metabolic bone disease. Increased mean value of serum BGP was noted in patients with hyperthyroidism, active acromegaly, hyperparathyroidism osteomalacia and some other metabolic bcne diseases. Conversely, decreased mean value of serum BGP was found in patients with hypothyroidism, hypoparathyroidism, Shee-han's syndrome and hypercortisolism. Normal serum BGP concentration was found in patients with simple goiter, thyroid adenoma, and inactive acromegaly. It was shown by the present data that the serum BGP as an index of bone formation, was very valuable in patients with endocrine and metabolic bone diseases.