钒酸钠对糖尿病大鼠的降糖作用

THE STUDY OF HYPOGLYCEMIC EFFECT AND ITS MECHANISM OF VANADATE ON STKEPTOZOTOCIN-DIABETZC RATS

为观察钒酸钠的降糖作用以及这种作用是否需要胰岛素介导,作者用钒酸钠治疗链脲佐菌素所致的糖尿病大鼠高血糖,并通过糖耐量试验以及离体胰腺灌流了解钒酸钠对胰岛素分泌的影响。结果发现钒酸钠具有降低链脲佐菌素糖尿病大鼠高血糖的作用,而这种降糖作用并不通过刺激胰岛素分泌。

Sodium orthovanadate is one of vanadate salts. When administered orally to STZ-induced diabetic rats, sodium orthovanadate may stimulate glucose uptake and. metabolism and made them normoglycemic. However, the blood glucose levels of normal rats treated with sodium orthovanadate did not change despite their plasma insulin levels decreased. The insulin-like effect of sodium orthovanadate on carbohydrate metabclism was not due to direct stimulation of insulin secretion, because the plasma insulin concentration of vanadate-treated STZ-rats remained lower and insulin secretion of isolated pancreas perfused with solution containing sodium orthovanadate was smilar to that of controls.