用晨尿黄体生成素测定监测排卵

PREDICTION OF OVULATION BY MEASURING URINARY LUTIENIZING HORMONE

测定54例不孕症晨尿黄体生成素(LH)峰值后24～72小时,并作诊断性腹腔镜、腹腔液及静脉血E_2测定和黄体中期孕酮测定,以判定LH峰值预测排卵的准确性。检测结果表明,腹腔镜见卵巢血体、排卵口及血性腹腔液等排卵表现有44例(81.5％);腹腔镜结合E_2比值证实有排卵者为87％。LH峰值预测排卵及黄体形成的准确性分别为87％和98％。仅1例未能证实排卵及黄体形成。LHEIA从月经周期第10天开始测定可不遗漏LH峰值,大多数可从周期第12天开始。

Diagnostic laparoscopy was carried out 24-72 hours after urinary luteinizing hormone (LH) surge in 54 patients Estradiol (E2) concentration was determined by radioimmunoassay (RIA) in peritoneal fluid and serum Serum progesterone (P) in midluteal phase was determined by RIA.The reliability of predicting ovulation by means of LH surge was evaluated according to the laparoscopic finding of ovulation and the measurements of E2-RIA and P-RIA. Typical findings of ovulation - corpus hemorrhagicum, ovulatory stigma and bloody fluid in cul-de-sac - were observed during laparoscopy in 44 patients among 54 cases with LH surge. Ovulation was confirmed directly by laparoscopy in 44 patients (81.5%). Ovulation was confirmed by combination of laparoscopy and E2 ratio in 47 cases (87%). Predictive rate of LH surge for ovulation and corpus luteum formation was 87% and 98% respectively. Only one patient could not be confirmed to have ovulation and corpus luteum formation by LH surge. Luteinizing hormone enzyme immunoassay (LHEIA) can be started from the 10th day of menstrual cycle without missing the LH surge. LHEIA can be started from the 12th day of cycle in most patients.