降低结肠癌术后复发和转移的体会

Experiences in decreasing the incidence of recurrence and metastasis prevention after radical colon cancer resections in 79 cases

目的 探讨降低结肠癌术后复发和转移发生率的方法。方法 回顾性分析 79例结肠癌在不同治疗方式后的复发和转移情况。结果 1990年前 17例行不规范根治术同时未进行化疗的病人术后复发或转移 9例 ( 5 2 .94% ) ;1990年后应用肿瘤隔离技术行规范根治性手术的病人中 ,10例不同时给予以化疗的术后复发或转移 3例 ( 3 0 % ) ,而 16例同时给予规则化疗的术后复发或转移仅 2例 ( 12 .5 % ) ,χ2 =6.18,P =0 .0 46。在肿瘤不能行根治切除的病例中 ,2 0例给予规则化疗 ,而另 16例未进行化疗 ,平均生存期分别为 8和 4.5个月。结论 重视术中肿瘤隔离技术 。

Objective To investigate the comprehensive therapy of colon cancer in order to improve the prognosis and decrease the incidence of recurrence and metastasis. Methods The clinical data of 79 patients with colon cancers were retrospectively analyzed and the treatment results of the different therapy were compared. Results Before 1990, recurrence or metastasis was found in 9 of 17 cases (52.94%) undergoing non-radical resections and without chemotherapy, whereas among those who were operated on according to no touchisolation technique resections after 1990's, recurrence occured in 16 cases in 5 years. On the other hand, 10 patients without chemotherapy, there were 3 cases (30%) with recurrent tumors in 5 years (χ 2=6.18, P=0.046). For patients with unresectable tumors, chemotherapy were given in 20 patients but the other 16 were not given, and the average survival periods were about 8 or 4.5 months, respectively (P<0.05). Conclusions Laying emphasis on no touchisolation technique during operation and using combined adjuvant therapeutic methods after surgical operations may benefit to the prevention of colon cancer recurrence and metastasis.