局部注射化疗药物和/或无水乙醇治疗原发性肝癌245例临床分析

Clinical analysis of 245 cases with primary hepatic carcinoma receiving intratumor injection of chemotherapy drugs and/or anhydrous alcohol

目的 探讨原发性肝癌有效的非手术替代疗法。方法 对 192例因各种原因不能进行手术治疗的原发性肝癌 (PHC)患者给予化疗药物配合无水乙醇癌灶内局部注射 ,对 5 3例PHC患者采用癌灶内单纯无水乙醇注射的方法进行治疗。根据治疗前后肿瘤的消长、血AFP水平的变化以及存活期的长短等评估疗效。结果 经治疗后大部分患者出现癌灶缩小和 或减少 ,血AFP水平下降 ,生活质量和存活期明显改善。化疗药物配合无水乙醇局部注射的治疗效果显著优于单纯无水乙醇注射者。

Objective To investigate the efficacy non-operative therapy for primary hepatic carcinoma (PHC). Methods 192 PHC cases were selected to receive the non-operative treatment of local intratumor injection of chemotherapy drugs combined with anhydrous alcohol, and 53 PHC cases received only the local injection of anhydrous alcohol. The therapeutic efficacy was evaluated according to the size changes of tumors, blood AFP level and the survival period. Results The size of tumors and blood AFP level in most cases were reduced significantly. The survival period of these patients were prolonged accordingly. Efficacy of intratumor injection of chemotherapy drugs combined with anhydrous alcohol was significantly better than that of only anhydrous alcohol. Conclusions Combinatorial intratumor injection of chemotherapy drugs and anhydrous alcohol is an rational and effective treatment for PHC.