阿尔茨海默病的康复治疗

An investigation of the rehabilitation efficacy in Alzheimer's disease

目的 探讨康复治疗对阿尔茨海默病 (AD)患者的有效性。方法 将 63例轻、中度AD患者分成 2组进行为期 8周的临床治疗 ,即康复组 (2 9例 )进行康复治疗 ,药物组 (3 4例 )应用盐酸多奈哌齐进行药物治疗。应用简易智能精神状态检查量表 (MMSE)、AD评定量表 (ADAS)及Blessed Roth痴呆量表判定疗效。结果 康复组患者的日常生活自理能力改善 (P <0 .0 5) ;药物组的认知功能 :MMSE较治疗前提高 3 .9分 (P <0 .0 5) ,ADAS认知部分 (ADAS cog)改善 4.8分 (P <0 .0 5) ,日常生活自理能力无明显变化 ,其中 2例(5.88% )出现轻度副作用 ;2组经治疗后的MMSE、ADAS认知部分和Blessed Roth评分进行比较 ,差异均有显著性意义 (P <0 .0 5)。结论 康复治疗能改善AD患者的日常生活自理能力 ;盐酸多奈哌齐可改善AD患者的认知功能 ,减轻痴呆的病情 ;整个治疗过程安全性好 ;

Objective To investigate the effect of rehabilitation intervention in treatment of Alzheimer's disease. Methods Sixty-three patients with AD were divided into two group s: Group A( n =29)underwent rehabilitation treatment and group B( n =34) was administered with oral intake of Donepezil. The efficacy was evaluated before a nd after treatment by the Mini-Mental State Examination (MMSE), the Alzheimer's Disease Assessment Scale-Cognition (ADAS-cog) and Blessed-Roth Scale. Results After 8 weeks of rehabilitation treatment, the pati ents' ability in daily life in group A was improved as indicated by the decrea se of Blessed-Roth Scores ( P < 0.05 ), while the cognition of AD patients was increased( P <0.05),as indicated by MMSE score and the cognitive portio n of ADAS scores ( P <0.05). There were significant differences between group A and group B in MMSE,ADAS-cog and Blessed-Roth Scale scores. Mild side effect was observed in 2 patients(5.88%). Conclusion Rehabi litation therapy could improve the ability of daily life of AD patients, while Donepezil was effective in improve the cognition of AD patients. Comprehensive interventions should be implemented for the AD patients.