血清LEPIGF-1与乳腺癌恶性表型的相关性研究

THE CORRELATION RESEARCH ON LEP IGF-1 AND THE MALIGNANT EXPRESSIONS OF FEMALE MAMMARY CANCER

目的 探讨血清瘦素 (LEP)、胰岛素样生长因子 1(IGF 1)、肿瘤坏死因子 α(TNF α)、雌二醇 (E2 )、睾酮 (T)及垂体泌乳素 (PRL)与女性乳腺癌患者临床分期、病理类型、腋窝淋巴结状态等之间的相互关系。方法 应用放免法和免放法 ,对 5 4例乳腺癌患者、2 8例乳腺良性病变患者及30例正常对照者血清中的LEP、IGF 1、TNF α、E2 、T和PRL浓度进行了测定 ,并与乳腺癌患者的其他临床资料进行对比分析。结果 乳腺癌组血清LEP水平显著高于正常对照组 (P <0 .0 5 ) ,血清IGF 1浓度显著低于正常对照组 (P <0 .0 5 )。正常对照组的TNF α、E2 和T分别与乳腺癌组和乳腺良性病变组存在显著性差异 (P <0 .0 5 ) ;血清PRL浓度在乳腺良性病变组、乳腺癌组以及正常对照组之间均无显著性差异 (P >0 .0 5 )。不同TNM分期、不同病理类型的乳腺癌患者之间各指标均无显著性差异 (P >0 .0 5 )。有腋窝淋巴结转移的乳腺癌患者血清LEP、IGF 1浓度显著高于无腋窝淋巴结转移的乳腺癌患者 (P <0 .0 5 ) ;绝经前乳腺癌患者的E2 浓度显著高于绝经后乳腺癌患者 (P <0 .0 5 )。结论 血清IGF 1与E2 相互作用可使乳腺癌的发病危险性升高 ;高浓度的LEP、IGF 1和低浓度TNF α可促进乳腺癌细胞的生长与转移。LEP、IGF

Objective To explore the correlation between the concentrations of LEP,IGF-1, TNF-α,E 2, T and PRL and such clinical expressions of female mammary cancer as clinical stages, pathological types, conditions of lumph node in axillary fossa.Methods The concentration determination of LEP, IGF-1, TNF-α,E 2, T and PRL was made in 28 cases of benign mammary lesions and 30 normal cases through RIA and IRMA, and the results were compared with other clinical data of patients.Results The concentration of LEP in serum was found much higher in the group of mammary cancer than in the normal group(P<0.01), while the content of IGF-1 was found much lower in the former group than that in the latter group(P<%). There existed significant differences between the normal group and the group of benign mammary lesions in terms of TNF-α, E 2 and T respectively(P<0.05) but with the concentration of PRL being an exception(P>0.05).No significant differences existed in terms of TNM stages and pathological types (P>0.05). The cases of mammary cancer with lymphatic metastasis have higher concentration of LEP, IGF-1 in serum than those cases without lymphatic metastasis(P<0.05).The concentration of E 2 in the cases of premenopausal mammary cancer was found higher than that postmemenopausal cases(P<0.01).Conclusion The interaction of IGF-1 and E 2 can contribute to the high risk of mammary cancer attack.High concentration of LEP and IGF-1 and low concentration of TNF-α can both accelerate the growth and transfer of mammary cancer cells. Because the changes in the concentrations of LEP and IGF-1 are closely related to the malignant expressions of mammary cancer, the detection of these indexes can help to diagnose mammary cancer.