青年尿毒症病人左心室舒张功能障碍及其影响因素

LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN YOUNG PATIENTS AND ITS CORRELATIVE FACTORS

目的 了解青年尿毒症病人左心室舒张功能障碍的发生率 ,并探讨心脏形态结构改变、高血压、贫血、水电解质紊乱及营养不良与左心室舒张功能障碍的关系。方法 随机选取住院的132例青年尿毒症病人进行彩色多普勒心脏超声检查 ,区分为左心室舒张功能障碍组和左心室舒张功能正常组 ,分析各组病人的影响因素。结果 经多元逐步判别分析 ,最后确定收缩压、血红蛋白浓度、左心房内径有判别意义 ,求出判别函数为 :Z =0 .131×收缩压 - 0 .0 4 2×血红蛋白浓度 +0 .111×左心房内径 - 3.6 6 7,Z >0判别为左心室舒张功能障碍。结论 青年尿毒症病人左心室舒张功能障碍多见 ,且发生较早 ,与收缩压、左心房内径和血红蛋白浓度有密切关系。

Objective To explore the occurrence rate of left ventricular diastolic dysfunction in young patients and the correlation of the disease and such factors as changes in cardiac morphosis,hypertension,anemia,water-electrolyte imbalance and malnutrition.Methods 132 young uremic patients treated from June,1998 to June,2003 were classified into the group of left ventricular diastolic dysfunction and the normal group according to the results of color doppler ultrasonic detection,and the correlative factors in both groups were analyzed as well.Results Systolic pressure,hemoglobulin concentration and left atrial diameter were found to have discriminatory value according to the multiple stepwise regression analysis.The special function was as follows.Z=0.131×value of systolic pressure-0.042×concentration of hemoglobulin +0.11×value of left atrial diameter-3.667,Z>0.Conclusion Left ventricular dysfunction occurs frequently and early in young uremic patients and has close relation to systolic pressure,left atrial diameter and hemoglobulin cencentration.