四例伴t(3;3)的急性髓系白血病的临床和实验室分析

Clinical and laboratory investigation of four acute myeloid leukemia patients with t(3;3) translocation

目的 探讨伴t(3;3)的急性髓系白血病 (AML)的临床和实验室特征。方法 骨髓细胞直接法和 2 4h短期培养法制备染色体 ,用R显带技术进行细胞遗传学分析。结果 4例患者的染色体核型分析结果均有t(3;3)的异常 ,临床和血液学改变符合AML诊断。 4例化疗后均未获得完全缓解 ,中位生存期为 4 .5个月。结论 t(3;3)是一种少见的核型异常 ,多存在于髓系白血病 ,其临床预后差。

Objective To investigate the clinical and laboratory characteristics of four acute myeloid leukemia with t(3;3) translocation. Methods Bone marrow cell chromosome karyotype analysis were carried out with direct method and short-term culture and R-banding technique. Results Four AML patients with t(3;3) translocation were identified. They did not obtain complete remission after chemotherapy and the median survival time was 4.5 months. Conclusions t(3;3) translocation is a rare chromosome abnormality,which has mostly been found in myeloid leukemia and the prognosis of these patients is poor.