肺心病呼吸衰竭时血液流变学变化与动脉血氧分压的关系

Relationship between PaO_2 and Alterations of Hemorheology in Patients of Chronic Cor Pulmonale with Respiratory Failure

作者对89例肺心病呼吸衰竭患者的动脉血PH、PaO,PaCO_2及相应的Hb、HCT、PT、Fb、Vb等进引了同步对比观察。结果表明:患者Hb、HCT、Vb均较正常值显著增高(P<0.01或0.05);PaO,降低之程度与其相应的血液流变学改变幅度之间呈显著正相关(P<0.01或0.05);在治疗有效的病例中,PaO_2的提高与相应的血液流变学改变呈显著负相关(P<0.05)。作者认为,肺心病呼吸衰竭时PaO_2与其血液流变学变化之间存在一定的规律性联系,后者可作为估计肺心病呼衰的缺氧程度和评价疗效的参考指标。

A synchronous observation of pH, PaO_2 and PaCO_2in contrast to their corresponding Hb, HCT and Vb was made in 89 cases of chronic cor pulmonale with respiratory failure.The results showed that the Hb, HCT and Vb of the patients were apparently higher than the normal (P<0.01 or 0.05 ); the reduction of PaO_2was positive linear-related to the alterations in hemorheology significantly (P<0.01); in the cases who had a good response to treatment, the elevation of PaO_2was negative linear-related to the hemorheological alterations statistically(P<0.05)。It suggests that there is a regular relationship between PaO_2and its corresponding alterations in hemorheology. The latter may be used as reference criteria to estimate the hypoxemia and the effectiveness of treatment for chronic cor pulmonale with respiratory failure.