党参花粉对小鼠慢性肝损伤的防治作用

Preventive and Curative effects of Bee Pollen of Codonopsis Pilosula Nannf on Chronis hepatic injury by CCl_4

用含6.8％党参花粉的饲料喂注射过四氯化碳(CCl_4)0.5ml/kg次/5天的小鼠,结果表明党参花粉能减轻CCl_4对小鼠肝脏的损伤,防止损伤所致血清白蛋白、肝脏蛋白的减少。形态学检查结果显示饲喂党参花粉的小鼠肝细胞脂变、坏死和轻微组织增生,修复完好。表明党参花粉对CCl_4所致的肝损伤具有保护作用。

During the period of the subcutaneous injection of CCl_4 0.5ml/kg, four times at intervals of 5 days, the C57 mice were fed with 6.8％ bee pollen of Codonopsis Pilosula Nannf (BPCPN). The results showed that BPCPN coule alleviate effctively the hepatic injury induced by CCl_4, and prevent the decrease of serum albumin and liver protein and glycogen after the liver was injured. The electron microscopis and pathologcal examination also showed that the mice had only slight hepatic necrosis, fat degeneration and fibrosis, but had a com plete repair as compared with the control groups. The above results indicated that BPCPN possessed preventive and curative on the impairment of CCl_4and could protect the hepatic metabolic function from the injury of CCl_4.