荞麦花粉水溶性黄酮组分对沙土鼠脑缺血重灌流损伤的保护效应

Effects of PFEM and SOD on Cerebral Ischemia Followed by Reperfusion in Gerbils

结扎沙土鼠双侧颈总动脉,继之重灌流,结果表明,荞麦花粉水溶性黄酮组分对沙土鼠急性脑缺血45分钟后重灌流6小时的卒中指数,及24小时的死亡率均有明显的保护效应,并与清除自由基的超氧化物歧化酶比较,提示荞麦花粉水溶性黄酮组分对沙土鼠脑缺血重灌流损伤的保护效应,可能与抗氧化作用有关。

By the ligation of gerbils bilateral carotid arteries and then reperfusion, the effects of PFEM and SOD on the stroke index were evaluated after a 45 min cerebral ischemia followed by a 6 hr reperfusion period and on the mortality after a 24 hr reperfusion period. The resulta indicated that both PFEM and SOD could decrease the stroke index and mortality dramatically. We speculated upon the protective effect of PFEM on cerebral damage following ischemia with reperfusion. It might be due to the inhibition of the free radical metabolism.