卡介菌多糖核酸预防慢性阻塞性肺疾病急性加重效应的临床观察

The prophylactic effect of BCG polysaccharides nucleic acid on the acute attack of chronic obstructive pulmonary disease

目的 :探讨卡介菌多糖核酸对慢性阻塞性肺病患者急性加重的预防作用及其机制。方法 :将 6 0名稳定期慢性阻塞性肺病患者随机分为治疗组和对照组 ,治疗组 30例接受卡介菌多糖核酸 0 .5 m g肌肉注射 ,隔日 1次 ,共 18次 ;两组患者均观察 6个月 ,每 2周门诊随访 1次 ,进行临床情况评价 ,治疗组于治疗前 3个月及 6个月检查血清 CD3、CD4 和 CD8水平。结果 :治疗组患者发生感染人数和感染天数均明显低于对照组 ,治疗后患者血 CD4 及 CD4 / CD8比值明显升高。结论 :卡介菌多糖核酸通过增强细胞免疫功能 。

Objective:To investigate the prophylactic effect of BCG polysaccharides nucleic acid(BCG-PSN)on patients with chronic obstructive pulmonary disease and its mechanism . Method :Sixty patients with chronic obstructive pulmonary disease were divided into two groups. In the treatment group, 30 patients received BCG-PSN 0.5mg intramuscular injection, QOD, for 18 times. All patients were followed up for 6 months, and the number of patients with acute attack and the number of days of its duration in 3 and 6 month were assessed. In treatment group, the blood samples were collected before treatment and 3 and 6 months after treatment for then measurement of the blood CD 3, CD 4 and CD 8. Results :In the treatment group, the number of patients with acute attack and the number of days were significantly lowered comparable to those in the control group. After treatment of BCG-PSN, blood CD 3, CD 4 and CD 8 were significantly increased. Conclusion:GCG-PSN has a good protection against the acute attack of chronic obstructive pulmonary disease, by way of the increment of the body cellular immune activity .