离子型有机锡化合物的研究(Ⅱ)──在有机碱存在下三烃基氯化锡和三苯基氢氧化锡同巯基乙酸的反应

Studies on Ionic Organotin Compounds(Ⅱ)──The Reaction of Trialkyltin Chloride and Triphenyltin Hydroxide withMercaptoacetic Acid in the Presence of Organic Bases

以三烃基氯化锡和三苯基氢氧化锡在有机碱存在下同巯基乙酸反应 ,合成了 1 6个离子型有机锡化合物 .化合物的结构经元素分析、IR、 1H NMR、 13 C NMR和 119Sn确认和表征 .对其反应机理进行了探讨 ,测定了部分化合物对 Bel-740 2和 KB癌细胞的抑制活性 .

The study of ionic tin compounds is current attention owing to their diversified molecular structure and wide range of application. Three kinds of ionic organotin compounds were obtained by the reaction of trialkyltin chloride and triphenyltin hydroxide with mercaptoacetic acid in the presence of organic bases. When Ph 3SnCl was treated with HSCH 2COOH, a novel complex [Ph 2ClSn (μ 2-SCH 2COO) ][R 3NH] was formed with the cleavage of Ph—Sn and the dephenylation mechanism was proposed and approved by Ph 3SnOH treated with HSCH 2COOH. All of the products were characterized by elemental analysis and 1H, 13 C, 119 Sn NMR. Antitumor activities of some compounds were tested for Bel-7402 and KB. The results show that the activities of compound B are better than compound A.