2-(1,2-亚乙/1,3-亚丙二硫)亚甲基-3-羰基丁酰氯的制备及其与芳烃的酰化反应

Preparation of 2-(1,2-Ethylene/1,3-Propylenedithio)methylene-3-oxo-butyryl Chloride and Their Acylation Reaction with Arenes

制备了较稳定的 2 -( 1 ,2 -亚乙 /1 ,3 -亚丙二硫 )亚甲基 -3 -羰基丁酰氯 ,并实现了其与芳烃的酰化反应 ,为 1 -芳基 -2 -( 1 ,2 -亚乙 /1 ,3 -亚丙二硫 )亚甲基 -1 ,3 -丁二酮的合成提供了一条新途径 .

As the α-elaboration strategy of the versatile α-oxo ketenedithioacetals, 2-(1,2-ethylene/1,3-propylenedithio)methylene-3-oxo-butyryl chlorides(3) were prepared via the sequential base-catalyzed hydrolysis of ethyl 2-(1,2-ethylene/1,3-propylenedithio)methylene-3-oxo- butyrate (1) and followed chlorination by sulfur oxychloride. 2-(1,2-Ethylene/1,3-propylenedithio)methylene-1-aryl- butane -1,3-diones(4) were synthesized by the Friedel-Crafts acylation of selected arenes with compound 3.