60例高危尿毒症患者肾移植术后环孢素A血药浓度的动态监测

Dynamic monitoring cyclosoprine A whole blood concentration of 60 patients with high risk uremia after the renal transplantation

目的 :总结不同高危尿毒症患者肾移植术后应用环孢素A(CsA)免疫抑制治疗时CsA谷浓度特点 .方法 :应用荧光偏振免疫法对 6 0例高危尿毒症患者肾移植术后不同时期的全血CsA浓度进行 4 71次动态监测 ,并以同期 2 4 3例中青年肾移植者全血CsA浓度 2 1 32次动态监测结果为对照 .结果 :高危尿毒症患者肾移植术后不同时期全血CsA谷值浓度明显高于对照组 ,平均升高了 2 3.2 % .结论 :动态监测高危尿毒症患者肾移植术后全血CsA浓度 ,可及时调整给药剂量 ,做到个体化用药 。

AIM: To study the characters of cyclosoprine A (CsA) immunosuppressive treatment and CsA whole blood concentration after renal transplantation among different high risk uremia patients. METHODS: CsA whole blood concentration in 60 cases ( n =471) of high risk uremia were dynamic monitoried by Fluorescence Polarization Immunoassay, It contrast by 243 cases ( n =2132) of young and middle aged renal transplantation patients. RESULTS: The CsA blood concentration of high risk uremia patients was much higher than that of the control at different stages after renal transplantation, it increased 23.2%. CONCLUSION: Dynamic monitoring whole blood concentration was helpful to prevent and relieve CsA side effect and to keep effective immunosuppressive therapy.