慢性牙周炎与心血管疾病

Chronic periodontitis and cardiovascular diseases

慢性牙周炎已成为心血管疾病的独立危险诱因 ,其危害可能比血清胆固醇水平、健康质量指标、糖尿病和吸烟等因素更为重要。慢性牙周炎促心血管疾病最可能的致病机制是细菌产物与各种凝血机制间的相互作用。LPS可导致TNF -α、IL - 1B和血栓因子A2 的释放。这些细胞因子可引起血小板的黏附和积聚 ,提高载脂泡沫细胞的形成和血管内膜胆固醇的沉积 ,使平滑肌异常增生 ,从而导致血管壁的增厚。

Chronic periodontitis,as an independent risk factor,is more strongly associated with cardiovascular diseases than other previous recognized risk factors,such as serum cholesterol levels,body mass index, diabetes and smoking status. The most likely common mechanism that links chronic periodontitis with cardiovascular diseases is an interaction between bacterial products and various haemeostatic mechanisms.Bacterial LPS can trigger the release of TNF-α,IL-1B and thromboxane A_2.These cytokines can initiate platelet adhesion and aggregation,promoting the formation of lipid-laden foam cells and the deposition of cholesterol in the intima,thus increase smooth muscle abnormal proliferation leading to thickening of the vessel wall.