巨细胞性心肌炎尸检1例报告及文献复习

Giant cell myocarditis: a case report and review of literature

目的 探讨巨细胞性心肌炎的临床病理特点、诊断及鉴别诊断。方法 通过光镜及免疫组化法 ,对 1例巨细胞性心肌炎尸体解剖病例进行病理组织学观察。结果 巨细胞性心肌炎的心脏增大 ,房室扩张 ,组织学观察心肌内可见大量多核巨细胞伴淋巴细胞、浆细胞及中性粒细胞浸润。心肌细胞变性、坏死。免疫组化染色多核巨细胞CD6 8( +)、desmin( - )。结论 巨细胞性心肌炎是一种少见的、具有独特临床病理特点的心肌炎症病变。

Objective To study the clinical pathological characteristics of giant cell myocarditis and its differential diagnosis. Methods An autopsy case of giant cell myocarditis was studied by histopathological observation and immunohistochemical staining. Results Histological examination presented numerous multinucleated giant cells mixed with lymphocytes, plasmacyte, neutrophils and some of eosinophils infiltration in the heart. Myocardium showed degeneration and necrosis. Immunohistochemical staining for giant cell were CD68 positive and desmin negative. Conclusion Giant cell myocarditis is a rare myocytic inflammatory disorder with specific clinical pathological characteristics.