病毒性脑炎患儿血清心肌肌钙蛋白的临床意义

Changes and clinical significance of serum cardiac troponin I in children with viral encephalitis

目的 研究血清心肌肌钙蛋白I(CTnI)水平对病毒性脑炎 (病脑 )并心肌炎或心肌损害患儿的诊断价值。方法 用酶联免疫吸附试验 (ELISA)测定 4 0例病脑患儿 (意识障碍组 12例 ,无意识障碍组 2 8例 ;惊厥组18例 ,无惊厥组 2 2例 )及 4 0例对照组血清心肌酶谱及CTnI水平。结果 病脑组血清心肌酶谱及CTnI阳性率明显高于对照组 (P <0 .0 5 ) ,同时有意识障碍组血清心肌酶谱及CTnI阳性率明显高于无意识障碍组 (P <0 .0 5 ) ,有惊厥组血清心肌酶谱和CTnI阳性率高于无惊厥组 (P均 <0 .0 5 )。结论 CTnI对病脑并心肌损害诊断有较高的特异性、敏感性 。

Objective To study the clinical significance and changes of serum cardiac troponin I (CTnI) levels in children's viral encephalitis merged with myocarditis or myocardium injury.Methods CTnI and myocardium zymogram levels were detected in 40 children with viral encephalitis and other 40 children as the controls by means of ELISA.Results CTnI and myocardium zymogram levels in viral encephalitis were significantly higher than those in controls(P<0.05). The positive rates of serum CTnI and myocardium zymogram was significantly higher in conscious disturbance than those in unconscious disturbance(P<0.05). The positive rate of serum myocardium zymogram was significantly higher in convulsion group than those in the nonconvulsion group(P<0.05)).The positive rate of CTnI had no significantly statistical difference between the convulsion group and nonconvulsion group (P<0.05).Conclusion CTnI is a highly sensitive, specific and much valuable maker in identifying viral encephalitis merged with myocarditis or myocardium injury, which may be helpful to the diagnosis,therapy and prognosis.