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活性氧与糖基化终产物致动脉粥样硬化作用的关系 被引量：3

Interaction of reactive oxygen species in atherogenetic properties of advanced glycation end products in diabetes
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摘要 There is overwhelming evidence for an involvement of reactive oxygen species(ROS) in the pathogenesis of atherosclerosis(AS) in diabetes mellitus(DM). For many years, knowledge on the contribution to diabetic complications and vascular disease induced by advanced glycation end-products(AGEs)has been rising. During the development of atherosclerosis, AGEs and ROS might have interaction. In this article, we provided four angles of view to discuss the role of ROS in the pathogenesis of atherosclerosis: the chemistry of ROS, the effect of vascular targets of ROS on activity of AGEs, the role of ROS in the pathogenesis of atherogenesis by AGEs, the same effect of ROS and AGEs-transcriptional regulation. [ There is overwhelming evidence for an involvement of reactive oxygen species(ROS) in the pathogenesis of atherosclerosis(AS) in diabetes mellitus(DM). For many years, knowledge on the contribution to diabetic complications and vascular disease induced by advanced glycation end-products(AGEs)has been rising. During the development of atherosclerosis, AGEs and ROS might have interaction. In this article, we provided four angles of view to discuss the role of ROS in the pathogenesis of atherosclerosis: the chemistry of ROS, the effect of vascular targets of ROS on activity of AGEs, the role of ROS in the pathogenesis of atherogenesis by AGEs, the same effect of ROS and AGEs-transcriptional regulation. [
作者 冯 刘乃丰
机构地区 东南大学心血管病研究所/附属中大医院心内科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2003年第12期1705-1708,共4页 Chinese Journal of Pathophysiology
关键词 活性氧 动脉硬化 糖尿病 Reactive oxygen species Arteriosclerosis Diabetes mellitus
分类号 R363 [医药卫生—病理学]
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参考文献15

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同被引文献46

  • 1张卫茹,侯凡凡,刘尚喜,郭志坚,周展眉,王国保,富宁,刘志强,王力,周玫.晚期糖基化终产物通过氧化应激加速动脉粥样硬化斑块形成[J].中华医学杂志,2004,84(13):1066-1070. 被引量：28
  • 2张隆,叶希韵,吕晔,李晓峰,王耀发.糖基化终产物和高糖对小牛主动脉血管细胞的损伤作用[J].基础医学与临床,2005,25(12):1161-1164. 被引量：2
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中国病理生理杂志
2003年 第12期

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