122例原发性肝癌HBV感染与AFP结果分析

Analysis of the Relationship between HBV and AFP in Primary Hepatic Carcinoma

目的 :探讨原发性肝癌 (PHC)患者 HBV感染及 AFP的关系。方法 :应用 EL ISA及放射免疫技术分别测定 12 2例原发性肝癌患者血清乙型肝炎病毒二对半 (HBV- M)及 AFP。结果 :12 2例 PHC患者中 ,HBs Ag阳性 110例(90 .2 % ) ,阴性 12例 (9.8% ) ,HBs Ag阳性者 AFP中位数 1110 ng/ m L,阴性者 14 7ng/ m L,二者有非常显著意义 (P<0 .0 0 5 ) ,HBs Ag阳性的 PHC患者 AFP升高的高峰年龄与其发病高峰年龄大致相符。 PHC患者 HBV感染模式分析中 ,HBV感染 117例 ,感染率为 95 .9% ,HBe Ab及 HBc Ab各项感染率分别为 90 .2 %、0 .8%、7.4 %、71.3%和 89.3% ;感染模式“小三阳”77例 (6 3.1% ) ,HBs Ag及 HBc Ab二项阳性 16例 (13.1% ) ,“大三阳”9例 (7.4 % ) ,HBs Ag及HBe Ab二项阳性 5例 (4 .1% ) ,全阴 5例 (4 .1% ) ,HBe Ab及 HBc Ab二项阳性 4例 (3.3% ) ,HBs Ag单项阳性 3例 (2 .5% ) ,HBs Ab、HBe Ab及 HBc Ab三项阳性 1例 (0 .8% ) ,HBc Ab单项阳性 1例 (0 .8% )。PHC患者 HBV- M及 AFP结果对比 ,HBV- M阳性者 AFP升高 (6 8.4 % )的比例明显高于 AFP正常组 (31.6 % ) (P<0 .0 0 5 ) ,而 HBV- M阴性者 AFP升高 (2 0 .0 % )的比例明显低于 AFP正常组 (80 .0 % ) (P<0 .0 1) ,HBV- M阳性者 AFP升高 (6 8.4 %

Purpose To research the relationship between HBV and AFP in primary hepatic carcinoma (PHC). Methods The antigen systems (HBV-M) and AFP were detected in 122 cases PHC with the method of ELISA. Results There were 110 HBsAg positive in the all, about 90.2 %, and negative 12, about 9.8 %, with the median of 1 110 ng/mL in positive ones and 147 ng/mL in negative ones which differ from each other obviously (P<0.005). The pike of AFP in PHC cases with positive HBsAg were the same of the pike of its attack. The model of HBV infection in patients of PHC analysis show that HBV infected 117 cases (95.9 %), every infective index of HBeAb and HBcAb were 90.2 %, 0.8%, 7.4 %, 71.3% and 89.3 % respectively; There 77 cases “secondary 3 positive” (HBsAg, HBeAg, HBcAg) in the infective model (63.1 %), 16 cases of “two positive” (HBsAg, HBcAb), about 13.1 %; 9 cases of “main 3 positive” (HBsAg, HBeAg, HBcAb), about 7.4 %, 5 cases of the other “two positive” (HBeAb and HBeAb), about 4.1 %, and 5 cases of “whole negative”, about 4.1 % as well. Comparison of HBV-M and AFP in PHC show that the rate of increased AFP in the group with positive HBV-M (68.4 %) was higher than those with normal HBV-M value (31.6 %),P<0.005, on the other hand, the rate of increased AFP in the group of negative HBV-M (20.0 %) was lower than those with normal HBV-M value (80.0 %), P<0.01. The rate of increased AFP in the group with positive HBV-M was obviously higher than those in the negative group (P<0.025). Conclusion HBV is a important pathogeny to PHC in which the increase of AFP have a close relationship with HBV infection.