血GPDA/尿GPDA比值测定对胃癌诊断的价值

The diagnostic value of the ratio of serum to urine contents of glycyl-proline dipeptidyl aminopep-tidase in gastric cancer

目的 探讨血清甘氨酰脯氨酸二肽氨基肽酶 (GPDA) /尿GPDA比值对胃癌的诊断价值。方法 采用连续监测法在Olym pusAU2 70 0全自动生化分析仪上测定 4 0例胃癌患者、18例胃癌合并淋巴结转移患者、2 5例贲门癌患者、6 8例胃肠良性病变患者及 90例正常人的血清GPDA和尿液GPDA ,计算血GPDA/尿GPDA比值 ,对其临床应用价值进行评价 ,并与血清GPDA的诊断价值进行比较。结果 以正常人血GPDA/尿GPDA比值 4 31为诊断界值 ,小于 4 31为阳性 ,对胃癌诊断的灵敏度为 87 5 % ,特异性为 97 0 % ,总符合率为 93 5 % ,均明显高于血清GPDA的测定。结论 血GPDA/尿GPDA比值测定作为一项新的诊断指标 ,对胃癌的诊断。

Objective To study the diagnostic value of the ratio of serum glycyl-proline dipeptidyl aminopeptidase (GPDA) to urine GPDA in patients with gastric cancer. Methods Serum GPDA and urine GPDA contents of 40 gastric cancer patients, 18 gastric cancer patients with metastasis to lymph glands, 25 patients with cancer in gastric cardia, 68 patients with benign gastric diseases, and 90 healthy persons were measured by continuous monitoring methods with an OLYMPUS AU2700 Autobiochemical Analyzer. To evaluate the diagnostic value of the ratio of serum GPDA to urine GPDA, we compared it with the diagnostic value of serum GPDA. Results The 5% digit (4.31) of serum GPDA/urine GPDA ratio of healthy persons was used as the cutoff point, those lower than it were regarded as positive. Its sensitivity and specificity for diagnosis of gastric cancer was 87.5% and 97.0%, respectively. Rate of conformity was 93.5%. Conclusion The ratio of serum GPDA/urine GPDA is a good marker for diagnosis and screening of gastric cancer.