双侧原发性乳腺癌雌激素与孕激素受体的表达及病理分析

Clinical and pathological analyses of estrogan receptor and progestin recetor expressions in bilateral breast cancer

目的 探讨双侧原发性乳腺癌中临床特点与病理学特征的关系及了解双侧原发性乳腺癌中雌激素受体 (Es troganreceptor,ER)、孕激素受体 (Progestinrecetor ,PR)表达情况。方法 回顾性分析了 2 9例双侧原发性乳腺癌ER、PR表达情况 ,分析其病理学特征及临床特点。结果 双侧乳腺癌发生率为 3 2 %,单侧乳腺癌ER、PR阳性表达分别为 5 3 2 %和 41 2 %,双侧乳腺癌中第一原发癌中ER、PR阳性表达分别为 69%和 5 1%,第二原发癌中分别为 65 %和 48%,浸润性小叶癌在单侧乳腺癌中占 11 6%,在双侧乳腺癌第一、二原发癌中分别占 3 4 4%和 41 3 %,单侧乳腺癌与双侧乳腺癌第一原发癌腋淋巴结状况相似。结论 双侧原发性乳腺癌有较高的ER表达 ,浸润性小叶癌与双原发癌发生有明显相关。

Objective To investigate the relationship between clinical and pathological features in order to observe estrogen and progestin receptor(ER and PR) expressions in bilateral primary breast cancer(BPBC). Methods ER and PR expressions in 29 cases of BPBC from 1990 to 2003 and the clinical and pathological features were analyzed retrospectively. Results ER and PR positive expressions were 53 2% and 41 2% in unilateral breast cancer, but 69% and 51% in first primary cancer of BPBC, and 65% and 41 3% in second primary cancer of BPBC, respectively. Invasive lobular carcinoma(ILC) was 11 6% in unilateral breast cancer and 34 4% in first cancer of BPBC and 41.3% in second primary cancer of BPBC. Status of lymph nodes in unilateral breast cancer was similar to that in BPBC. Conclusion There is higher ER expression in BPBC than that in unilateral breast cancer. ILC is significantly related to the carcinogenesis of BPBC. The status of lymph nodes is not related to BPBC.