老龄大鼠尿动力学及膀胱逼尿肌结构改变的实验研究

Changes of urodynamics and detrusor structure of aging rats

目的 探讨老龄后膀胱结构功能的改变。方法 以 2 4月龄大鼠为老龄组 ,6月龄大鼠为青龄组 ,通过充盈期膀胱测压和膀胱逼尿肌组织Masson法染色 ,对两组大鼠的尿动力学指标和膀胱逼尿肌的不同组织进行对照比较。结果 充盈期膀胱测压老龄大鼠最大膀胱容量显著增加 ,漏尿点压无明显差异。老龄大鼠逼尿肌不稳定的发生率较青龄组高 ;逼尿肌组织结构老龄大鼠逼尿肌中纤维组织显著增加 ;平滑肌成分显著减少。结论 老龄可引起大鼠膀胱结构功能改变 ,其机制有待于深入研究 。

Objective To investigate the changes of urinary bladder structure and function of aging rats. Methods The aging group and the young adult group were composed of 24 month old rats and 6 month old rats, respectively. The urodynamic changes were studied with filling cystometry, structural changes by Masson stain and image analysis. Results Filling cystometry revealed that the maximum bladder capacity increased in the aging rats. No difference in leak point pressure was found in the two groups. The occurrence rate of the detrusor instability in aging group was higher than that in young adult group. In bladder structure, fibrous tissue increased significantly but smooth muscle decreased significantly in the detrusor of aging rats. Conclusion Aging may lead to changes of rat bladder structure and function, but its mechanism needs to be further studied.