钙粘素和增殖相关抗原在非小细胞肺癌中的表达及临床意义

Expression levels of E-cd and Ki67 in non-small cell lung carcinoma and the clinical significance

目的 探讨上皮钙粘素 (E cd)和增殖相关抗原 (Ki67)在非小细胞肺癌 (NSCLC)中的表达及癌细胞发生侵袭、转移过程中的意义。方法 收集 62例NSCSLC患者标本 ,采用免疫组化S P法检测E cd和Ki67抗原的表达水平。结果 E cd在Ⅲ～Ⅳ期和Ⅰ～Ⅱ期的阳性表达率分别为 3 3 3 %和 65 7%,Ki67在Ⅲ～Ⅳ期和Ⅰ～Ⅱ期的阳性表达率分别为( 96 3 %)和 ( 68 6%) ,伴有或不伴有癌旁转移的NSCLC病例间其E cd和Ki67阳性表达水平差异均有显著性意义。结论 E cd和Ki67的表达水平与NSCLC侵袭、转移密切相关 。

Objective To investigate the expression levels of E cadherin (E cd) and proliferation related antigen Ki67 and their roles in the mechanism of invasion and metastasis of non small cell lung carcinoma(NSCLC). Methods The expression levels of E cd and Ki67 antigen were detected by immunohistochemistry. Results The positive rates of E cd in the cases of Ⅲ Ⅳ stage and Ⅰ Ⅱ stage were 33 3% and 65 7%, respectively, but those of Ki67 were 96 3% and 68 6%. The expression levels of E cd and Ki67 in cases with metastasis were significantly different from those in cases without metastasis. Conclusion The expression levels of E cd and Ki67 are closely associated with invasion and metastasis of NSCLC. The expression level of E cd is negatively correlated with that of Ki67 in NSCLC.