激素联合低分子肝素治疗肾病综合征合并高凝状态的疗效探讨

Investigation on Treatment of Nephrotic Syndrome and High Condense Status with Hormone and Low Molecular Weight Heparin

目的探讨原发性肾病综合征(NS)合并高凝状态的治疗方法和效果。方法将30例 NS 合并高凝状态患者采用激素联合低分子肝素(LMWH)治疗,观察治疗前后血、尿指标及血液流变学的变化。结果治疗3个疗程后,观察指标:血脂、血液流变学、尿蛋白定量等均明显低于治疗前,而血清白蛋白明显高于治疗前。总有效率为86.7%。结论激素联合低分子肝素治疗 NS 可以促使其缓解,使尿蛋白排泄量减少,降低高凝状态且元明显的副作用。

Objective To investigate the effects of treatment for nephrotic syndrome and high condense status(NS).Methods 30 patients with NS were treated with low molecular weight heparin(LMWH)and hormone. The index of blood,urine and hemorheology before and after treatment were observed.Results After three months's treatment,the index such as blood lipid,hemorheology and the ratio of urine protein were lower than before treatment and the blood albumin was higher than before.The total effective rate was 86.7%.Con- clusion The LMWH combined hormone may reduce the excretion of urine protein and ease the high condense status and can not have adverse effect signifcantly.