选择性亚低温对神经外科重症的临床疗效及对免疫功能的影响

Clinical effect of selective mild hypothermia on severe neurosurgery patients and influence on immuno- logical function

目的观察选择性头部亚低温对神经外科重症的临床疗效及对免疫功能的影响。方法 40例神经外科重症患者(包括21例重型颅脑损伤患者及19例行手术治疗的严重脑出血患者),随机分为对照组18例和选择性头部亚低温治疗组22例,检测治疗前后 IgG、IgA、IgM、C_3、C_4及 T 细胞亚群和自然杀伤细胞(NK cell)活性及预后(GOS)变化。结果选择性亚低温治疗组与对照组相比,治疗前后患者免疫功能无明显差异(P>0.05),死亡率降低,恢复良好率提高,预后显著改善(P<0.05)。结论选择性头部亚低温治疗对神经外科重症患者免疫功能无影响。选择性亚低温治疗安全有效,可降低死亡率,改善预后。

Objective To investigate the clinical effect of selective brain-located mild hypothermia on severe neurosurgery patients and influence to immunological function.Methods 40 severe neurosurgery pa- tients(including 21 patients with severe brain injury and 19 severe patients with cerebral hemorrhage under- went operation)were randomly divided into the selective hypothermic group(22 cases)and control group(18 cases),and the concentration of IgG,IgA,IgM,C3,C4 and T lymphocyte sub-population,NK cell activity and prognosis(GOS)were evaluated.Results Contrasted with the control group,the immunological function of the patients had no significantly differenee before or after treatment in selective hypothermic group(P>0.05),the mortality decreased and good recovery cases increased,the prognosis of the patients improved (P<0.05) ,Con- elusion Selective mild hypothermic therapy has no influence on the immunological function of the severe neu- rosurgery patients.Selective mild hypothermia is safe and effective,which can reduce the mortality and improve the prognosis.