哌啶乙醇酯类化合物的合成及其灭钉螺效果的研究

Synthesis of piperidino-ethoxylated esters and their molluscidal effects

目的 设计并合成哌啶乙醇酯类化合物及研究它们的灭钉螺效果。方法 以哌啶乙醇盐酸盐为母体 ,通过酯化反应引入不同的酰基合成哌啶乙醇酯类化合物 ,采用WHO提出的完全浸泡法研究槟榔碱、合成产物的灭钉螺效果。结果 合成了四个哌啶乙醇酯类化合物 ;在不同浓度 (10mg/L、1 0mg/L、0 1mg/L)下 ,槟榔碱、化合物Ⅱ和Ⅳ、氯硝柳胺的 2 4h灭螺率 ,分别为 95 5 %、92 0 %、84 0 % ;98 9%、88 9%、77 8% ;95 6 %、86 4 %、71 5 % ;10 0 %、77 8%、6 4 4 % (P >0 0 5 ) ;在浓度为 1 0mg/L时 ,以上四种药液 2 4h对钉螺的开厣率分别为 94 3%、85 6 %、92 8%和 0 0 0 % (P <0 0 5 )。 结论 槟榔碱、化合物Ⅱ和Ⅳ有较强的灭螺效果 ,对钉螺的开厣率 ,槟榔碱、化合物Ⅱ和Ⅳ高于氯硝柳胺。

To design and synthesize the piperidino-ethoxylated esters and to study their molluscidal effects,4 piperidino-ethoxylated esters were synthesized by esteration with piperdino-ethanol and immersion method issued by WHO(1965) as 'Final Screen Method in Molluscidal Laboratory',The 24 hrs molluscidal rates of arecoline,synthesized compound Ⅱ,Ⅳ and niclosamide at 3 different concentrations(10mg/L,1.0mg/L,0.1mg/L) were 95.5%,92.0%,84.0%;98.9%,88.9%,77.8%;95.6%,86.4%,71.5%,100%,77.8%,64.4% respectively.It concludes that arecoline,synthesized compound Ⅱ and Ⅳ show the highest molluscidal effects.For the rate of operculum-opening of oncomelania,arecoline,compound Ⅱ and Ⅳ are greater than niclosamide.