血浆纤维蛋白原水平的影响因素及其临床意义

Effects of Plasma Fibrinogen Levels and Plasma Fibrinogen Levels’s Clinical Significance

目的 :探讨遗传与环境因素对血浆纤维蛋白原水平的影响 ;研究血浆纤维蛋白原在冠心病发病中的作用。方法 :从正常查体人员中随机选择 10 5例血浆纤维蛋白原水平大于 4 g/L者作为实验组 ,在同一人群中按年龄、性别 1:1配比的原则 ,选择血浆纤维蛋白原水平小于 4 g/L者作为对照组 ;深入现场 ,检测可能与血浆纤维蛋白原水平有关的因素 ,采用条件Logistic回归分析研究各因素对血浆纤维蛋白原水平的影响 ;并随访比较了不同血浆纤维蛋白原水平者一级亲属的血浆纤维蛋白原水平和心血管疾病的发生情况。结果 :体重指数 ,高脂肪饮食 ,吸烟 ,体力活动少 ,高血压 ,甘油三酯 ,高密度脂蛋白 ,低密度脂蛋白 ,一级亲属的血浆纤维蛋白原水平等 9个因素进入回归方程 ;高纤维蛋白原者的一级亲属 ( 6 .1± 0 .8g/L )明显高于低纤维蛋白原者的一级亲属的 ( 4 .4± 0 .5 g/L ) ;血浆纤维蛋白原浓度高者CHD的发病率 ( 2 4 % )高于血浆纤维蛋白原低者 ( 10 % )。结论 :遗传和环境因素均对血浆纤维蛋白原水平有一定的影响 ;血浆纤维蛋白原浓度升高是CHD发病的独立危险因素。

Objective: To explore the effects of inherited and environmental factors on plasma fibrinogen levels, identify plasma fibrinogen levels's clinical significance in diagnosis of cardiovascular disease.Methods:105 samples of high plasma fibrinogen levels (more than 4 g/L )were randomly selected from health check people; according to age and sex accordance principle, we selected 105 person of low plasma fibrinogen levels (less than 4 g/L ) and regard them as control groups. We surveied effects of two groups' factors that maybe effect plasma fibrinogen levels and carried through Logistic regress analysis. in addition to, we have analysied family spectrum and compared to coronary heart disease(CHD) incidence rate between high plasma fibrinogen levels group and low plasma fibrinogen levels group. Results: Many factors are found to affect fibrinogen levels, such as body mass index, high fat diet, smoking, little physical exercise, hypertension, high triglycerides, low-density lipoprotein. The plasma fibrinogen levels of the first relatives in high plasma fibrinogen levels group(6.1±0.8 g/L )was significantly higher than that in low plasma fibrinogen levels group(4.4±0.5 g/L ). CHD incidence rate in high plasma fibrinogen levels group was significant higher than that in low plasma fibrinogen levels group within 3 years follow up.Conclusion: Environment and genetic all affect plasma fibrinogen levels, high plasma fibrinogen levels was an independent risk predictors to CHD.