肝硬化患者血浆降钙素原、IL-18检测及临床意义

Detection and clinical significance of plasma procalcitonin and IL-18 in patients with liver cirrhosis

探讨肝硬化患者血浆降钙素原 (Procalcitonin ,PCT)、IL - 18水平变化及临床意义。采用免疫发光法和ELISA法测定 98例肝硬化患者和 30例正常对照者血浆PCT、IL - 18水平。肝硬化患者血浆PCT、IL - 18水平显著高于正常对照组 ,自发性细菌性腹膜炎 (SBP)组显著高于非SBP组 (均P <0 0 1) ,二者水平呈正相关 (r =0 36 4 ,P <0 0 1)。随Child分级升高 ,上述指标逐渐递增 ,血浆PCT、IL - 18水平与TBil水平均呈正相关 (r =0 4 4 5和 0 4 12 ,均P <0 0 1) ;PCT与ALT之间无明显相关性 (r=0 173,P >0 0 5 ) ,而IL - 18与ALT呈正相关 (r=0 5 0 2 ,P <0 0 1)。

To investigate the changes of plasma procalcitonin (PCT)、IL-18 levels and their clinical significance in patients with liver cirrhosis. Plasma PCT and IL-18 levels in 98 patients with liver cirrhosis and 30 normal control(NC) were determined by immunoluminometric assay and ELISA, respectively. Plasma PCT、IL-18 levels in all patients were significantly higher than those in NC group, higher in spontaneous bacterial peritonitis (SBP) group than non SBP (P<0.01) and the positive relationship were found between them (r=0.364,P<0.01). Following the increasing of Child grading, the two parameters above increased subsequently. Plasma level of PCT、IL-18 showed positively correlated with TBil level (r=0.445、0.412,P<0.01);there was positive correlation between plasma IL-18 level and ALT (r=0.502,P<0.01) but not in plasma PCT level (r=0.173,P>0.05). The combined detection will be helpful for the evaluation of the state of hepatic function and severity degree of disease.