含三磷酸腺苷的复方麻黄素滴鼻制剂对纤毛运动影响的初步探讨

Preliminary study on the effect of compound ephedrine nasal drops containing ATP on ciliary movement

目的 探讨三磷酸腺苷 (ATP)对麻黄素滴鼻制剂对纤毛运动的影响。方法 以离体蟾蜍上腭黏膜为模型 ,研究 1%麻黄素、复方麻黄素、ATP及含ATP的复方麻黄素滴鼻制剂对纤毛运动的影响。结果 4种滴鼻制剂与生理盐水的相对纤毛运动时间持续百分率分别为 :1%麻黄素为 91 8% ,复方麻黄素为 4 2 8% ,ATP为 110 5 % ,含ATP的复方麻黄素制剂为 87 7%。结论 复方麻黄素滴鼻剂对纤毛毒性较大 。

Objective To investigate the effect of compound ephedrine nasal drops on the ciliary movement.Methods Using toad palate as model in vitro, the effect on ciliary movement was studied for 1% ephedrine, compound ephedrine,ATP,and compound ephedrine containing ATP.Results The relative percentage of the lasting time of ciliary movement of the four nasal drops compared with normal saline:1% ephedrine was 91.8%, compound ephedrine was 42.8%, ATP was 110.5% and compound ephedrine containing ATP was 87.7%.Conclusion Ciliotoxcity of compound ephedrine is distinct relatively, but it can be reduced by ATP.