传染性出血坏死性肠炎伴肾小管坏死

Infective hemorrhagic necrotic jejuno-ileitis with diffuse degeneration and necrosis of renal tubule:an autopsy report and review of the literature

目的 探讨传染性出血性坏死性肠炎的病理变化及其发病机制。方法 对 1例患病死亡者的尸检资料进行眼观、光镜、电镜检查 ,结合流行病学及文献进行分析。结果 病变主要表现为节段性出血性坏死性空回肠炎及肾小管上皮弥漫性变性坏死和早期修复性改变 ,伴有肝、肺、脑等器官中毒性损害性病变。结论 传染性出血性坏死性肠炎可能系EHECO15 7∶H7通过其志贺样毒素。

Purpose To study the pathological changes and pathogenesis mechanism of infective hemorrhagic necrotic jejuno ileitis. Methods A case of infection by autopsy examination was studied by light and electronic microscopy with review of the literature. Results The pathological changes were segmental, hemorrhagic, necrotic jejuno ileitis with diffuse degeneration and necrosis of renal tubule with early stage of the repair. The toxic injury of other organs, such as the liver, the lung and brain, was also observerd. Conclusions EHEC O157∶H7 may cause severe enteritis and extraintestinal complication by Shiga like toxin, the locus of enterocyte effacement pathogenicity island and hemolysin.