肝内胆管癌30例的临床病理特征及预后分析

Clinical analysis of the relationships between clinical pathologic factors and survival time in intrahepatic cholangiocarcinoma:a report of 30 cases

目的 :探讨肝内胆管癌 (intra hepaticcholangiocarcinoma ,ICC)的临床病理特征及治疗与预后的关系。方法 :回顾性分析 1991～ 1999年山东省立医院、济宁医学院附属医院 3 0例ICC患者病理、临床资料。结果 :ICC比肝细胞癌少见且预后不良 ,手术切除是目前较理想治疗方式 ,影响预后的因素是肿瘤边缘、淋巴结转移与组织病理情况。根治切除术后 1年生存率 5 3 3 % ,3年生存率 3 3 3 %。结论 :根治性切除是最有效的治疗方法。

OBJECTIVE:To study the clinic pathologic characteristics and the outcome of the patients with intrahepatic cholangiocarcinoma(ICC).METHODS:A total of 30 ICC patients in Shandong Provincial Hospital and the Affiliated Hospital of Jining Medical College were selected for clinicopathologic analysis.RESULTS:The morbidity rate of ICC was fewer than HCC,and ICC patients had poor prognosis.At present,surgical resection is the only helpful method for these patients.Tumor margin,lymph node metastasis,histological type were significant risk factors for poor outcome of ICC.The 1 year survival rate of patients with curative resection was 53 3%,3 years survival rate 33 3%.CONCLUSIONS:Curative resection remains the most effective approach in the treatment of ICC.