1,6-二磷酸果糖醛缩酶对无水酒精注射治疗原发性肝癌中的观察

The Value of The Measurement of Fructose 1,6-Diphosphate Aldolase in Evaluating of Tumorous Tissue Damage by Percutaneous Ethanol Injection Therapy of Hepatocellular Carcinoma

目的:探讨血清1,6-二磷酸果糖醛缩酶(FDP-ALD)测定对经皮肝穿无水酒精瘤内注射术(PEI)治疗原发性肝癌的疗效评价。方法:18例共24个肝癌肿瘤结节行PEI治疗,检测治疗后不同时点的血清FDP-ALD和甲胎蛋白(AFP)的变化并进行比较。结果:血清FDP-ALD活性在第1次PEI术后达最高值,随后呈波浪状下降,第8次回到术前水平,提示血清FDP-ALD活性变化可反映肝癌组织的坏死程度。血清AFP浓度治疗后也呈下降趋势,术前、术后比较差异有显著性(P<0.05)。结论:血清FDP-ALD活性测定可用于肝癌PEI的疗效评价,对AFP阴性的肝癌患者也有判断疗效的价值。

Objective: The purpose of this study was to evaluate the value of fructose 1,6-diphosphate aldolase(FDP aldolase) in detected tumorous tissue damaged by Percutaneous Ethanol Injection(PEI) in patients of Hepatocellular Carcinoma(HCC). Methods: There were18 patients with 24 tumor nodules treated by Percutaneous Ethanol Injection, Changes in serum levels of FDP aldolase activities were analyzed at different time after PEI treatment,and the levels of serum alpha-fetoprotein (AFP) were also measured. These indexes were compared. Results: Serum levels of FDP aldolase were increased (P<0.05) after the first PEI treatment and thereafter decreased just like the wave. After the eighth PEI, it came back to the levels of pre-treatment. Changes in serum levels of FDP Aldolase indicated tumor tissue necrosis in HCC. Serum levels of AFP were decreased after treatment, it also indicating adequate tumor tissue necrosis. Conclusions: The measurement of FDP aldolase activities in serum after PEI treatment is clinically useful to detect the degree of tumorous tissue damage, especially for the cases that AFP are negative.