斑秃患者外周血IGF-I水平及皮损处IGF-IR的检测

Detection of IGF-I level in the blood of patients with alopecia areata and expression of IGF-IR in their skin lesions

目的 : 研究胰岛素样生长因子I(IGF I)在斑秃患者外周血中的水平及皮损区IGF IR的表达 ,探讨其与斑秃的发病关系。方法 : 应用放射免疫法测定了IGF I在 46例斑秃血清中的水平 ,并以 2 0例正常人血清为对照 ;应用免疫组化方法检测了 30例斑秃患者皮损区IGF IR的表达 ,并以 16例正常人头皮作对照。结果 : 斑秃患者血清中IGF I水平明显低于正常对照 ,活动期与静止期相比无明显差别 ;皮损区IGF IR表达明显低于正常对照。结论 : 斑秃患者外周血IGF -I水平和皮损区IGF IR表达的改变可能与斑秃的发病有关。

Objective:To determine the level of IGF-I in the sera of the patients with alopecia areata (AA), the expression of IGF-IR in the lesions of AA, and the relationship between IGF-I/IGF-IR and the pathogenesis of AA. Methods:The sera of 46 patients with AA were detected with radioimmunoassay (RIA) and 20 healthy volunteers were used as controls; The expression of IGF-IR in the lesions of 30 AA patients was detected with immunohistochemistry, compared with 16 normal scalp specimens. Results: It was found that the level of IGF-I in AA sera was lower compared with controls. There was no significant difference between active stage and stable stage of the disease. The level of IGF-IR in the lesions of AA was decreased when compared with controls. Conclusions:The changes of IGF-I and IGF-IR may be associated with pathogenesis of AA.