28例急性淋巴细胞白血病细胞遗传学研究

STUDIES ON CYTOGENETIC CLASSIFICATION OF ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDHOOD

对28例急性淋巴细胞白血病患者的骨髓细胞进行了染色体分析,结果发现:21例(75%)具有克隆性染色体异常。其中数目异常7例(25%),结构异常5例(17.86%),数目和结构异常并存者9例(32.14%)。染色体类型与预后关系十分密切。易位者的预后极差,6q-患者预后较好,超二倍体的预后明显好于亚二倍体。这表明细胞遗传学分型对患者预后的估计和治疗方案选择提供了科学的依据。

Bone marrow chromosomes of 28 children with acute lymphoblastic leukemia (ALL) were analysed by direct and short-time culture bone marrow chromosome techniques. The results revealed that 21 cases (75%) had clonal chromosomal abnormalities, including 7 cases with modal number abnormalities, 5 cases with structural abnormalities, and 9 cases with both. The category of the karyotype is closely related with out- come. The patients with translocations had poor prognosis, but those with 6qhad better outcome. The children with hyperdiploidy had better prognosis than those with hypodiploidy.The studies show that cytogenetic classification is very useful in treatment and in prediction of prognosis.