纳洛酮对颅脑外伤患者神经功能的保护作用

Effect of naloxone neurologic protection after traumatic brain injury

目的 探讨纳洛酮对颅脑外伤后神经功能保护的作用及其意义。方法 采用按入院顺序配对实验法 ,将 86例中重型颅脑外伤的患者分为两组 ,对比其疗效。结果 治疗组格拉斯哥昏迷评分 (GCS)由 7.95± 2 .12上升为 12 .85± 4.12 ,血内皮素含量由 95 .2 3± 12 .12下降为 5 4.65± 9 .0 5 ,脑电图 (EEG)的异常率由 91.60 %下降为 49.5 5 % ,与对照组比较差异均有显著性 (P <0 .0 5 )。结论 颅脑外伤的治疗中早期加用纳洛酮 ,具有增加脑灌注量、减轻脑水肿等功效 ,对患者神经功能的保护具有重要意义。

Objective To investigate the effect of naloxone on neurologic protection after brain trauma.Methods By a mate experimental method,86 patients with traumatic brain injury were divied into two groups and the curative effectiveness was compared.Results GCS in the treatment group was increased from 7.95±2.12 to 12.85±4.12,endothelin content decreased from 95.23±12.12 to 54.65±9.05,abnormal EEG decreased from 91.60% to 49.55% (all P <0.05).Conclustion An early larger dosage of Naloxone can relieve traumatic brain edema and protect neural cells.