非特异性肉芽肿性前列腺炎4例临床病理观察

Nonspecific granulomatous prostatitis: a clinicopathologic study of 4 cases

目的 观察非特异性肉芽肿性前列腺炎的临床病理特点。方法 通过光镜、免疫组化和特染方法 ,对 4例非特异性肉芽肿性前列腺炎穿刺组织进行病理组织学观察。结果 4例非特异性肉芽肿性前列腺炎均表现尿路梗阻症状 ,肛门指诊前列腺质硬、结节感 ;3例临床印象前列腺癌 ,1例血PSA高于正常。镜下炎症以前列腺导管及腺泡为中心呈小叶状分布 ,导管及腺泡有不同程度的炎症和破坏 ,部分区域导管及腺泡结构消失 ,可见淋巴细胞、中性粒细胞、嗜酸性粒细胞和上皮样组织细胞弥漫性浸润 ,上皮样组织细胞LCA和CD6 8(+)。结论 组织形态、免疫组化、特染和病史相结合可以正确诊断该病。

Objective To study the clinicopathological characteristics of nonspecific granulomatous prostatitis. Methods Four cases of nonspecific granulomatous prostatitis were studied by histopathological observation, immunohistochemical and special staining in needle biopsied tissues. Results All the patients of nonspecific granulomatous prostatitis complained urinary obstruction, and digital rectal examination showed that prostate were large, lobular and firm. Three cases were clinically suspected prostatic carcinoma, and serum PSA level was elevated in 1 case. Histopathologically, inflammation was lobular distuibution around prostatic tubuloalveolar glands. The prostate glands showed some degree of inflammation and destrction, even complete loss ofglandular structures. There were diffuse infiltrations of epithelioid histiocytes, lymphocytes, neutrophils, and eosinophils arround the glands. Conclusion Nonspecific granulomatous prostatitis can be diagnosed by combination of histopathology with immunohistochemical and special staining.