妊高征患者蜕膜组织中淋巴细胞转化率及细胞因子活性的变化

Change of Decidual Tissue Lymphocyte Transforming Ratio and Activity of Cytokines

目的:研究妊娠高血压综合征(简称妊高征)的免疫学发病机制。方法:通过测定妊高征患者及正常孕妇蜕膜组织中淋巴细胞转化率,检测细胞培养液上清中白细胞介素-1(IL-1)、白细胞介素-2(IL-2)及肿瘤坏死因子α的活性,探讨妊高征的免疫学发病机制。结果:实验组淋巴细胞转化率、IL-1、IL-2、TNF-α活性均比对照组高,有显著统计学意义。且IL-2活性升高与淋巴细胞转化率存在明显的直线正相关。结论:蜕膜组织中的细胞因子异常升高及T细胞可能处于高免疫激活状态参与了妊高征的免疫学发病机制。

Objective: To study the immunological mechanism in pregnancy induced hypertension syndrome (PIH syndrome).Methods: Ratio of lymphocyte transforming and production of interleukin-1, interleukin-2, tumor necrosis factor-alpha were measured in PIH patient and normal pregnant women. Results: In decidual tissue of patients with PIH syndrome, the ratio of lymphocyte transforming and the production of interleukin-1, interleukin-2, turner necrosis factor-alpha rised. Conclusion: Secretions of interleukin-1, interleukin-2, turner necrosis factor alpha of monocytes/macrophages and T lymphocytes are higher significantly, proportion of lymphocyte transforming increases, which could possibly be involved in the immunological mechanism of PIH syndrome.