原发性高血压患者微量白蛋白尿与脑小动脉硬化的关系

The Relationship between Microalbuminuria and Brain Arteriolar Sclerosis in Essential Hypertension

目的 探讨原发性高血压 (EH)患者微量白蛋白尿 (MCA)与亚临床脑血管损害的关系。方法 84名EH患者按 2 4小时尿MCA值分为异常微量白蛋白组 (MCA组 )和正常微量白蛋白组 (NMCA组 ) ,应用二维超声测定颈动脉内膜中层厚度 (IMT)及斑块 ,头颅CT或头颅MRI评价腔隙性脑梗死。结果 MCA组颈总动脉内膜—中层厚度 ,斑块的严重程度 ,发生腔隙性脑梗死患者比例均高于NMCA组 (P <0 0 0 1) ,差别有显著性意义。结论 合并有MCA的EH患者脑小动脉硬化更显著。

objective To explore the relationship between Microabuminuria(MCA) and brain arteriolar sclerosis in essential hypertension(EH). Methods eighty_four inpatients with essential hypertension were divided into two groups according to 24_hour albumin excretion. Carotid IMT was assessed by B_model ultrasound examination and cerebral lacunar lesion was measured by MRI or CT. Results Microalbuminuria patients had higher carotid IMT and greater plaque in CCA and had a higher prevalence or cerebral ischemic lacunae(P<0.001) than normoalbuminuric patients. Conclusions Microalbuminuric patients had greater brain arteriolar sclerosis.