脑出血急性期神经元特异性烯醇化酶的变化及临床研究

Changes and clinic research of neuron-specific enolase in acute cerebral hemorrhage

目的 探讨脑出血急性期血清神经元特异性烯醇化酶 (NSE)浓度变化及其与神经功能缺损和预后之间的关系。方法 用酶联免疫分析法分析测定 4 0例脑出血患者和 2 0例健康人血清 NSE浓度。神经功能缺损评定按 SSS标准 ,出血量以入院时 CT结果计算。结果 脑出血患者血清 NSE浓度明显高于正常对照组 (P<0 .0 5 ) ,与出血量呈明显正相关 (P<0 .0 5 ) ,与神经功能缺损程度呈正相关 (P<0 .0 5 ) ,与预后呈负相关 (P<0 .0 5 )。结论 脑出血急性期检测血清 NSE浓度 ,有助于判断神经功能缺损程度及预后。

Objective To explore changes of serum neuron-specific enolase(NSE) in acute cerebral hemorrhage patients,the relations of NSE to neurologic damage and prognosis.Methods Serum NSE levels were determined with ELISA from 40 patients with cerebral hemorrhage and 20 normal controls,neurological damage were valued with Scandivia stroke scale(SSS).The volumes of hematoma were measured with cranial CT scan.Results The serum NSE levels of patients were significantly higher than those of controls(P<0.05) and positive correlated with the volumes of hematoma(P<0.05) and with SSS(P<0.05) but negative correlated with prognosis(P< 0.05).Conclusions Measurements of serum NSE levels of acute cerebral hemorrhage patients will be useful to determine the degree of neurologic demage and prognosis.