摘要
老年期痴呆主要包括阿尔茨海默病 (Alzheimerdisease ,AD)、血管性痴呆 (vasculardementia ,VD)等 ,是临床常见病和多发病。研究发现 ,晚期糖基化终产物 (advancedglycationendproducts ,AGEs)在老年期痴呆发病机制中具有重要作用。大量的资料证明 ,AD、VD患者体内存在着这种重要的毒性产物 ,它与衰老、痴呆的发生密切相关 ,其病理机制与氧化应激。
Senile dementia as a common disease mainly includes Alzheimer′s disease(AD),vascular dementia(VD).recently investigations showed that advanced glycation end products(AGEs) play an important role in senile dementia.Increasing evidence suggested that AGEs regarded as poison products exist in the AD and VD.This article reviews the role of AGEs in AD and VD.
出处
《现代医学》
2004年第2期125-128,共4页
Modern Medical Journal
关键词
糖基化终产物
阿尔茨海默病
血管性痴呆
衰老
advanced glycation end products
Alzheimer disease
vascalar dementia
senility
